Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of Treponema pallidum subsp. pallidum, the syphilis spirochete.
S. Kumar, M. J. Caimano, A. Anand, A. Dey, K. L. Hawley, M. LeDoyt, C. La Vake, A. R. Cruz, L. G. Ramirez, L. Pastekova, I. Bezsonova, D. Smajs, J. C. Salazar, J. D. Radolf
The paper analyzes sequence variation in β-barrel domains of OMPs in TPA clinical strains, finding that genetic exchange and host selection pressures drive OMP diversity and inform vaccine strategies.
bioRxiv · May 9, 2018Microbiology