Author

A. R. Cruz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:statistical model· 1

Frequent Co-Authors

S. H. M. Rooijakkers· 2 shared A. Anand· 1 shared A. Dey· 1 shared A. E. H. Bentlage· 1 shared A. J. R. Heck· 1 shared A. Lux· 1 shared C. J. C. d. Haas· 1 shared C. J. C. de Haas· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

S. H. M. Rooijakkers

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3 papers

Recent·Most cited

Staphylococcal protein A inhibits IgG-mediated phagocytosis by blocking the interaction of IgGs with FcγRs and FcRn

A. R. Cruz, A. E. H. Bentlage, R. Blonk, C. J. C. d. Haas, P. C. Aerts, L. M. Scheepmaker, I. G. Bouwmeester, A. Lux, J. A. G. v. Strijp, F. Nimmerjahn, K. P. M. v. Kessel, G. Vidarsson, S. H. M. Rooijakkers

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

A. R. Cruz, M. A. den Boer, J. Strasser, F. J. Beurskens, C. J. C. de Haas, P. Aerts, G. Wang, R. N. de Jong, F. Bagnoli, J. van Strijp, K. P. M. van Kessel, J. Schuurman, J. Preiner, A. J. R. Heck, S. H. M. Rooijakkers

This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.

bioRxiv · Jul 20, 2020Microbiology

Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of Treponema pallidum subsp. pallidum, the syphilis spirochete.

S. Kumar, M. J. Caimano, A. Anand, A. Dey, K. L. Hawley, M. LeDoyt, C. La Vake, A. R. Cruz, L. G. Ramirez, L. Pastekova, I. Bezsonova, D. Smajs, J. C. Salazar, J. D. Radolf

The paper analyzes sequence variation in β-barrel domains of OMPs in TPA clinical strains, finding that genetic exchange and host selection pressures drive OMP diversity and inform vaccine strategies.

bioRxiv · May 9, 2018Microbiology