Author

K. L. Hawley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. D. Radolf· 4 shared J. C. Salazar· 3 shared A. L. Greninger· 2 shared C. J. LaVake· 2 shared L. G. Ramirez· 2 shared L. Giacani· 2 shared M. J. Caimano· 2 shared N. A. P. Lieberman· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

J. D. Radolf

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells

T. B. Reid, C. Godornes, V. L. Campbell, K. J. Laing, L. C. Tantalo, A. Gomez, T. N. Pholsena, N. A. P. Lieberman, T. M. Krause, V. I. Cegielski, L. A. Culver, N. Nguyen, D. Q. Tong, K. L. Hawley, A. L. Greninger, , D. M. Koelle

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

bioRxiv · Feb 27, 2024Immunology

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

M. Ferguson, K. N. Delgado, S. McBride, I. C. Orbe, C. J. LaVake, M. J. Caimano, Q. Mendez, T. F. Moraes, A. B. Schryvers, M. A. Moody, J. D. Radolf, M. Weiner, K. L. Hawley

This paper uses the Epivolve phage display method to generate monoclonal antibodies targeting a subdominant epitope on Treponema pallidum BamA, showing opsonic activity in macrophage assays.

bioRxiv · May 13, 2023Immunology

High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny

N. A. P. Lieberman, T. D. Armstrong, B. Chung, D. Pfalmer, C. M. Hennelly, A. Haynes, E. Romeis, Q.-Q. Wang, R.-L. Zhang, C.-X. Kou, G. Ciccarese, I. Dal Conte, M. Cusini, F. Drago, S.-i. Nakayama, , A. L. Greninger

The paper uses nanopore sequencing to analyze repeat regions in T. pallidum genes, revealing clade-specific patterns that align with whole genome phylogeny.

bioRxiv · Aug 2, 2022Microbiology

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and - independent phagosomal signals that contribute to phagocytosis and inflammation

S. J. Benjamin, K. L. Hawley, M. P. Vera-Licona, C. J. LaVake, J. L. Cervantes, R. Burns, O. Luo, Y. Ruan, M. Caimano, J. D. Radolf, J. C. Salazar

This study investigates MyD88-dependent and -independent phagosomal signaling in macrophages during Borrelia burgdorferi infection, showing their roles in phagocytosis and inflammation.

bioRxiv · Mar 30, 2019 · PreprintImmunology

Sequence variation of rare outer membrane protein β-barrel domains in clinical strains provides insights into the evolution of Treponema pallidum subsp. pallidum, the syphilis spirochete.

S. Kumar, M. J. Caimano, A. Anand, A. Dey, K. L. Hawley, M. LeDoyt, C. La Vake, A. R. Cruz, L. G. Ramirez, L. Pastekova, I. Bezsonova, D. Smajs, J. C. Salazar, J. D. Radolf

The paper analyzes sequence variation in β-barrel domains of OMPs in TPA clinical strains, finding that genetic exchange and host selection pressures drive OMP diversity and inform vaccine strategies.

bioRxiv · May 9, 2018Microbiology