Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells
A. Sznarkowska, A. Kostecka, A. Kawiak, P. Acedo, M. Lion, A. Inga, J. Zawacka-Pankau
The paper shows that protoporphyrin IX stabilizes and activates TAp73, inducing apoptosis in TP53-deficient cancer cells by disrupting interactions with MDM2/MDMX and inhibiting degradation by Itch.
bioRxiv · Aug 15, 2018Cancer Biology