In vitro and in vivo combination of lytic phages and octapeptin OPX10053 against B-lactamase-producing clinical isolates of Klebsiella pneumoniae
O. Pacios, L. Blasco, I. Bleriot, L. Fernandez-Garcia, M. Lopez-Diaz, C. Ortiz-Cartagena, A. Barrio-Pujante, F. Fernandez-Cuenca, B. Aracil, J. Oteo-Iglesias, K. A. Hansford, M. Tomas
This study evaluates the in vitro and in vivo synergy between lytic phages and octapeptin OPX10053 against K. pneumoniae clinical isolates, showing synergistic activity but toxicity concerns with OPX10053.
bioRxiv · Mar 15, 2023 · PreprintMicrobiology