Author

M. M. Jepsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

A. Stein· 2 shared K. Lindorff-Larsen· 2 shared A. Valanciute· 1 shared D. M. Fowler· 1 shared H. Zschach· 1 shared L. Nygaard· 1 shared R. Hartmann-Petersen· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

A. Stein

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2 papers

Recent·Most cited

Accurate protein stability predictions from homology models

A. Valanciute, L. Nygaard, H. Zschach, M. M. Jepsen, K. Lindorff-Larsen, A. Stein

This study evaluates the accuracy of protein stability predictions from homology models compared to crystal structures, finding they perform equally well when sequence identity is at least 40%.

bioRxiv · Jul 12, 2022Biophysics

Classifying disease-associated variants using measures of protein activity and stability

M. M. Jepsen, D. M. Fowler, R. Hartmann-Petersen, A. Stein, K. Lindorff-Larsen

The paper classifies PTEN missense variants as pathogenic or benign using experimental and computational methods, finding that ~60% of pathogenic variants destabilize the protein.

bioRxiv · Aug 2, 2019 · PreprintBiophysics