Author

A. Valanciute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Stein· 2 shared K. Lindorff-Larsen· 2 shared A. Lima· 1 shared A.-M. Ochocka-Fox· 1 shared D. M. Fowler· 1 shared F. V. N. Din· 1 shared H. Zschach· 1 shared J. Blackmur· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

A. Stein

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Author profile →

3 papers

Recent·Most cited

Accurate protein stability predictions from homology models

A. Valanciute, L. Nygaard, H. Zschach, M. M. Jepsen, K. Lindorff-Larsen, A. Stein

This study evaluates the accuracy of protein stability predictions from homology models compared to crystal structures, finding they perform equally well when sequence identity is at least 40%.

bioRxiv · Jul 12, 2022Biophysics

Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

M. Cagiada, K. E. Johansson, A. Valanciute, S. V. Nielsen, R. Hartmann-Petersen, J. J. Yang, D. M. Fowler, A. Stein, K. Lindorff-Larsen

The paper analyzes variant effects on protein activity and abundance in NUDT15 and PTEN, finding that a third of variants cause loss of function and half of these also reduce abundance.

bioRxiv · Sep 28, 2020Biophysics

Aspirin-mediated DKK-1 increase rescues Wnt-driven stem-like phenotype in human intestinal organoids

K. Dunbar, A. Valanciute, V. Rajasekaran, T. Jamieson, P. Freile Vinuela, A. Lima, J. Blackmur, A.-M. Ochocka-Fox, M. J. Arends, O. J. Sansom, K. B. Myant, S. M. Farrington, M. G. Dunlop, F. V. N. Din

The paper shows aspirin reduces Wnt-driven stem-like traits in intestinal organoids by increasing DKK-1, suggesting a mechanism for its anti-cancer effects.

bioRxiv · Oct 17, 2019 · PreprintCancer Biology