OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
G. Beyrend, T. C. van der Sluis, E. T. I. van der Gracht, T. Abdelaal, S. P. Jochems, R. A. Belderbos, T. H. Wesselink, S. van Duikeren, F. J. van Haften, A. Redeker, E. Beyranvand Nejad, M. Camps, K. L. M. C. Franken, M. M. Linssen, P. Hohenstein, , R. Arens
This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.
bioRxiv · Dec 24, 2021 · PreprintImmunology