S. P. Jochems

Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity

This study develops a high-throughput method to analyze polysaccharide-specific B cells using combinatorial multimer staining and spectral flow cytometry, revealing associations with serotype specificity, vaccination history, and geographic origin.

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.

Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

Minimally-invasive nasal sampling in children offers accurate pneumococcal colonization detection

This study shows that nasal lining fluid filter strips provide equal pneumococcal detection sensitivity to deep nasopharyngeal swabs in children, offering a less unpleasant alternative.

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

Experimental Human Challenge Reveals Distinct Mechanisms of Acquisition or Protection Against Pneumococcal Colonization

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.

Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage

This study shows that influenza virus infection impairs innate immune responses to pneumococcal carriage in the nose, increasing bacterial density through cytokine-driven mechanisms.