Author

R. Arens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Approach:experimental assay· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. van Duikeren· 3 shared E. Beyranvand Nejad· 2 shared E. T. I. van der Gracht· 2 shared F. Ossendorp· 2 shared G. Beyrend· 2 shared I. N. Pardieck· 2 shared K. L. M. C. Franken· 2 shared L. Cicin-Sain· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

S. van Duikeren

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

G. Beyrend, T. C. van der Sluis, E. T. I. van der Gracht, T. Abdelaal, S. P. Jochems, R. A. Belderbos, T. H. Wesselink, S. van Duikeren, F. J. van Haften, A. Redeker, E. Beyranvand Nejad, M. Camps, K. L. M. C. Franken, M. M. Linssen, P. Hohenstein, , R. Arens

This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.

bioRxiv · Dec 24, 2021 · PreprintImmunology

A third vaccination with a single T cell epitope protects against SARS-CoV-2 infection in the absence of neutralizing antibodies

I. N. Pardieck, E. T. I. van der Gracht, D. M. B. Veerkamp, F. M. Behr, S. van Duikeren, G. Beyrend, J. Rip, R. Nadafi, T. C. van der Sluis, E. Beyranvand Nejad, N. Mulling, D. J. Brasem, M. G. M. Camps, S. K. Myeni, P. J. Bredenbeek, , R. Arens

A third dose of a single T cell epitope vaccine protects mice from SARS-CoV-2 infection without neutralizing antibodies by enhancing effector-memory and tissue-resident memory T cells.

bioRxiv · Dec 15, 2021 · PreprintImmunology

Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation

M. A. Aslam, M. F. Alemdehy, E. M. Kwesi-Maliepaard, M. Caganova, I. N. Pardieck, T. van den Brand, F. I. Muhaimi, T. van Welsem, I. de Rink, J.-Y. Song, E. de Wit, R. Arens, K. Rajewsky, H. Jacobs, F. van Leeuwen

This study identifies DOT1L as a key regulator of B cell differentiation by controlling epigenetic programs that maintain B cell naivety and support germinal center formation.

bioRxiv · Mar 25, 2020Immunology

Off-target effects of Cre recombinase reveal limits of adoptive T cell transfers and persistent proliferation of effector CD8 T-cells

L. Borkner, A. Drabig, X. Zheng, J. Drylewicz, T. Marandu, M. Baliu-Pique, S. van Duikeren, R. Arens, K. Tesselaar, J. A. Borghans, L. Cicin-Sain

The paper shows that effector memory T-cells (TEM) proliferate during persistent CMV infection, maintaining memory inflation, while central memory T-cells (TCM) do not proliferate as much.

bioRxiv · Dec 20, 2018 · PreprintImmunology