H. Mei

Multimodal profiling of peripheral blood identifies proliferating circulating effector CD4+ T cells as predictors for response to integrin α4β7-blocking therapy in patients with inflammatory bowel disease

USP18 is an essential regulator of muscle cell differentiation and maturation

This study identifies USP18 as a critical regulator of muscle cell differentiation and maturation, independent of its role in the ISG response.

Lineage tracing via associative chromosome/plasmid barcoding with siBar

The paper introduces siBar, a method for tracking plasmid and chromosomal lineages in bacteria, and evaluates its barcode complexity through an evolution experiment.

OX40 agonism enhances efficacy of PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum

This study shows that OX40 agonism improves PD-L1 checkpoint blockade by altering T cell differentiation, leading to enhanced anti-tumor immunity through dynamic expression of NK and chemokine receptors.

Immunological profiling of COVID-19 patients with pulmonary sequelae

This study examines immune cell profiles in COVID-19 survivors with and without pulmonary sequelae one year post-discharge, identifying immune imbalances linked to residual lung damage.

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

Ex vivo detection of SARS-CoV-2-specific CD8+ T cells: rapid induction, prolonged contraction, and formation of functional memory

This study identifies SARS-CoV-2-specific CD8+ T-cell responses, showing their rapid induction, prolonged contraction, and functional memory formation compared to antibody responses.

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

CACTUS integrates genomic and transcriptomic data to map single tumor cells to their clonal origins, improving accuracy in follicular lymphoma by combining exome, RNA-seq, and B-cell receptor sequencing.

Doublecotin-like kinase 1 increases chemoresistance of colorectal cancer cells through the anti-apoptosis pathway

This study shows that DCLK1 overexpression in colorectal cancer cells increases chemoresistance to 5-Fu by suppressing caspase gene expression and inhibiting apoptosis.

The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease

This study uses metagenomic next-generation sequencing to analyze the respiratory virome in COPD exacerbations, finding high sensitivity and specificity for viral detection and a correlation between viral presence and reduced bacteriophage abundance.

METAGENOMIC SEQUENCING FOR COMBINED DETECTION OF RNA AND DNA VIRUSES IN RESPIRATORY SAMPLES FROM PAEDIATRIC PATIENTS

This study evaluates an in-house mNGS protocol for detecting RNA and DNA viruses in pediatric respiratory samples, showing high concordance with PCR and identifying additional pathogens not detected by routine methods.

A high resolution view of adaptive events

This study tracks mutations during coadaptation between E. coli and plasmid pBR322 using duplex sequencing, revealing clonal interference and chromosomal variant emergence as key adaptive events.