Author

M. M. McDonnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Emerman· 2 shared A. Gaba· 1 shared A. S. Dingens· 1 shared B. Flath· 1 shared J. D. Bloom· 1 shared K. H. Crawford· 1 shared L. Chelico· 1 shared S. C. Karvonen· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

M. Emerman

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2 papers

Recent·Most cited

Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms

M. M. McDonnell, S. C. Karvonen, A. Gaba, B. Flath, L. Chelico, M. Emerman

This paper creates synthetic APOBEC3 proteins with enhanced antiviral activity against HIV-1 through non-catalytic mechanisms, comparable to the most potent natural APOBEC3 variant.

bioRxiv · Apr 6, 2021Microbiology

APOBEC3C tandem domain proteins create super restriction factors against HIV-1

M. M. McDonnell, K. H. Crawford, A. S. Dingens, J. D. Bloom, M. Emerman

The paper shows that synthetic tandem domain APOBEC3C proteins create more potent antiviral factors against HIV-1 than native A3C, with increased resistance to viral antagonism.

bioRxiv · Mar 27, 2020Microbiology