Automated optimisation of solubility and conformational stability of antibodies and proteins
A. Rosace, A. Bennett, M. Oeller, M. M. Mortensen, L. I. Sakhnini, N. Lorenzen, C. Poulsen, P. Sormanni
This study introduces an automated computational method to co-optimize solubility and conformational stability of antibodies, validated on six antibodies with improved developability without affecting antigen-binding.
bioRxiv · May 20, 2022Biochemistry