Author

N. Lorenzen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

T. P. J. Knowles· 2 shared T. W. Herling· 2 shared A. Bennett· 1 shared A. Konomi· 1 shared A. L. Ejdrup· 1 shared A. Rosace· 1 shared C. Poulsen· 1 shared F. Herborg· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

T. P. J. Knowles

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Author profile →

4 papers

Recent·Most cited

Non-specificity fingerprints for clinical stage antibodies in solution

T. W. Herling, G. I. Invernizzi, H. Ausserwoeger, J. R. Bjelke, T. Egebjerg, S. Lund, N. Lorenzen, T. P. J. Knowles

This study characterizes non-specific interactions of clinical-stage monoclonal antibodies using solution-based microfluidic technologies to generate quantitative non-specificity fingerprints.

bioRxiv · Feb 13, 2023 · PreprintBiophysics

Automated optimisation of solubility and conformational stability of antibodies and proteins

A. Rosace, A. Bennett, M. Oeller, M. M. Mortensen, L. I. Sakhnini, N. Lorenzen, C. Poulsen, P. Sormanni

This study introduces an automated computational method to co-optimize solubility and conformational stability of antibodies, validated on six antibodies with improved developability without affecting antigen-binding.

bioRxiv · May 20, 2022Biochemistry

Surface interaction patches link non-specific binding and phase separation of antibodies

H. Ausserwöger, G. Krainer, T. J. Welsh, T. Sneideris, M. M. Schneider, G. Invernizzi, T. W. Herling, N. Lorenzen, T. P. J. Knowles

This study links antibody non-specific binding to surface interaction patches and shows how they drive liquid-liquid phase separation under certain conditions.

bioRxiv · Mar 7, 2022 · PreprintBiophysics

Relative enrichment - a density-based colocalization measure for single-molecule localization microscopy

A. L. Ejdrup, M. D. Lycas, N. Lorenzen, A. Konomi, F. Herborg, K. L. Madsen, U. Gether

The paper introduces a density-based colocalization measure for SMLM data, demonstrating its application on simulated and neuronal data.

bioRxiv · Feb 8, 2022 · PreprintCell Biology