ImmunologybioRxiv
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
B. Goldman-Israelow, E. Song, T. Mao…·A. Iwasaki
This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.
DOI 10.1084/jem.20201241