C. B. Wilen

Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB

The paper identifies JADE3 as an antiviral activator of the NF-kB pathway through a CRISPR activation screen against influenza A virus.

Survey of white-footed mice in Connecticut, USA reveals low SARS-CoV-2 seroprevalence and infection with divergent betacoronaviruses

The study surveys white-footed mice in Connecticut, finding low SARS-CoV-2 seroprevalence and identifying two divergent betacoronaviruses.

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

Simultaneous and sequential multi-species coronavirus vaccination

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.

Inflammasome activation in infected macrophages drives COVID-19 pathology

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy

This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication

This study investigates the effect of NSAIDs on SARS-CoV-2 infection and finds that COX-2 is induced by the virus but NSAIDs do not impact viral entry or replication.

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

Neuroinvasion of SARS-CoV-2 in human and mouse brain

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.