Pharmacology & ToxicologybioRxiv
Isoprenylcysteine carboxylmethyltransferase basedtherapy for Hutchinson Gilford progeria syndrome
B. Marcos-Ramiro, A. Gil-Ordonez, N. I. Marin-Ramos…·S. Ortega-Gutierrez
This study develops UCM-13207, an ICMT inhibitor that reduces progerin nuclear accumulation and improves phenotypes in progeria models.