Isoprenylcysteine carboxylmethyltransferase basedtherapy for Hutchinson Gilford progeria syndrome
B. Marcos-Ramiro, A. Gil-Ordonez, N. I. Marin-Ramos, F. J. Ortega-Nogales, M. Balabasquer, P. Gonzalo, L. Rolas, A. Barkaway, S. Nourshargh, V. Andres, M. Martin-Fontecha, M. L. Lopez-Rodriguez, S. Ortega-Gutierrez
This study develops UCM-13207, an ICMT inhibitor that reduces progerin nuclear accumulation and improves phenotypes in progeria models.
bioRxiv · Jul 23, 2020Pharmacology & Toxicology