Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment.
T. A. Tockary, S. Abbasi, M. Masai, N. Yoshinaga, S. Fukushima, K. Kataoka, S. Uchida
This paper develops an mRNA vaccine platform that integrates immunostimulatory dsRNA into antigen-encoding mRNA to enhance cancer immunotherapy, showing effective activation of dendritic cells and therapeutic effects in mouse models.
bioRxiv · Jan 18, 2022Bioengineering