Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage
S. Ciudad, E. Puig, T. Botzanowski, M. Meigooni, A. S. Arango, J. Do, M. Mayzel, M. Bayoumi, S. Chaignepain, G. Maglia, S. Cianferani, V. Orekhov, E. Tajkhorshid, B. Bardiaux, N. Carulla
This paper determines the structures of Aβ(1-42) tetramers and octamers in membrane-mimicking environments and identifies a new mechanism of membrane disruption via hydrophilic edge pores.
bioRxiv · Sep 12, 2019Biophysics