Author

S. Cianferani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

O. Hernandez-Alba· 3 shared H. Gizardin-Fredon· 2 shared T. Botzanowski· 2 shared A. Beck· 1 shared A. De Reynies· 1 shared A. Henras· 1 shared A. Hirschler· 1 shared A. Kamoun· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersBiophysics

O. Hernandez-Alba

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Author profile →

8 papers

Recent·Most cited

Denaturing mass photometry for straightforward optimization of protein-protein cross-linking reactions at single-molecule level

H. Gizardin-Fredon, P. E. Santo, M.-E. Chagot, B. Charpentier, T. M. Bandeiras, X. Manival, O. Hernandez-Alba, S. Cianferani

This paper introduces denaturing mass photometry (dMP) for optimizing protein cross-linking reactions, offering faster and more accurate analysis than SDS-PAGE.

bioRxiv · May 30, 2023Biophysics

The Ribosome Maturation Factor Rea1 utilizes nucleotide independent and ATP hydrolysis driven Linker remodelling for the removal of ribosome assembly factors

J. Busselez, G. Koenig, T. Klos, P. Sosnowski, N. Marechal, H. Gizardin-Fredon, S. Cianferani, C. Dominique, Y. Henry, A. Henras, H. Schmidt

This study investigates how Rea1 removes ribosome assembly factors by showing its linker undergoes nucleotide-independent and ATP hydrolysis-driven remodelling to interact with the MIDAS domain.

bioRxiv · Nov 3, 2022Biochemistry

Large-scale conformational changes of FhaC provide insights into the two-partner secretion mechanism

G. Sicoli, A. Konijnenberg, J. Guerin, S. Hessmann, E. Del Nero, O. Hernandez-Alba, S. Lecher, G. Rouaut, L. Mueggenburg, H. Vezin, S. CIANFERANI, F. Sobott, R. Schneider, F. Jacob-Dubuisson

The paper investigates conformational changes in FhaC, a TpsB transporter, revealing how it facilitates protein secretion without external energy sources through intrinsic dynamics.

bioRxiv · Nov 9, 2021Biophysics

An original structural fold underlies the multitask P1, a silencing suppressor encoded by the Rice yellow mottle virus

V. Poignavent, F. Hoh, G. Terral, Y. Yang, F.-x. Gillet, J. H. Kim, F. Allemand, E. Lacombe, C. Brugidou, S. Cianferani, H. Demene, F. Vignols

The paper determines the 3D structure and dynamics of P1, a silencing suppressor from Rice Yellow Mottle virus, revealing structural features and their roles in viral infectivity.

bioRxiv · Feb 24, 2020 · PreprintPathology

Middle-level IM-MS and CIU experiments for improved therapeutic immunoglobulin isotype fingerprinting

T. Botzanowski, O. HERNANDEZ-ALBA, M. Malissard, E. Wagner-Rousset, E. Desligniere, O. Colas, J.-F. Haeuw, A. Beck, S. CIANFERANI

This paper introduces middle-level IM-MS and CIU methods for improved mAb isotyping, showing better differentiation of IgG isotypes compared to intact-level analysis.

bioRxiv · Jan 20, 2020 · PreprintBiophysics

CRISPR-based bioengineering of the Transferrin Receptor revealed a role for Rab7 in the biosynthetic secretory pathway

M. Deffieu, I. Cesonyte, F. Delalande, G. Boncompain, C. Dorobantu, E. Song, V. Lucansky, A. Hirschler, S. Cianferani, T. Xu, F. Perez, C. Carapito, R. Gaudin

The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.

bioRxiv · Jan 5, 2020 · PreprintCell Biology

PPARG is a tumor suppressor in basal bladder tumors offering new potential therapeutic opportunities.

L. Coutos-Thevenot, S. Beji, H. Neyret-Kahn, Q. Pippo, J. Fontugne, J. Osz, C. Krucker, C. Dos Santos Groeneveld, F. Dufour, A. Kamoun, M. Ley, E. Chapeaublanc, A. De Reynies, T. Lebret, Y. Allory, , I. BERNARD-PIERROT

The paper identifies PPARγ as a tumor suppressor in basal bladder tumors and suggests therapeutic opportunities through PPARγ activation.

bioRxiv · Dec 9, 2019 · PreprintCancer Biology

Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

S. Ciudad, E. Puig, T. Botzanowski, M. Meigooni, A. S. Arango, J. Do, M. Mayzel, M. Bayoumi, S. Chaignepain, G. Maglia, S. Cianferani, V. Orekhov, E. Tajkhorshid, B. Bardiaux, N. Carulla

This paper determines the structures of Aβ(1-42) tetramers and octamers in membrane-mimicking environments and identifies a new mechanism of membrane disruption via hydrophilic edge pores.

bioRxiv · Sep 12, 2019Biophysics