G. Maglia

Unravelled proteins form blobs during translocation across nanopores

This study investigates protein translocation through nanopores, finding that blob-like structures form during transport, and identifies conditions for single-file transport.

An engineered electroosmotic flow transports unravelled proteins across nanopores

This paper introduces an engineered electroosmotic flow to transport unfolded proteins across nanopores for non-enzymatic identification and sequencing.

Design guidelines for α-helical peptides that self-assemble into transmembrane barrel pores killing antibiotic-resistant bacteria

This study designs α-helical peptides that self-assemble into transmembrane barrel pores, effectively killing antibiotic-resistant bacteria with low human cell toxicity.

Bottom-up fabrication of a multi-component nanopore sensor that unfolds, processes and recognizes single proteins

This paper describes the fabrication of a multi-component nanopore sensor that unfolds, processes, and recognizes single proteins using a 28-component proteasome-nanopore complex.

Substrate binding and turnover modulate the affinity landscape of dihydrofolate reductase to increase its catalytic efficiency

The paper shows that substrate binding and turnover modulate the affinity landscape of DHFR to enhance catalytic efficiency by inducing allosteric changes and energy-driven conformational switches.

Modeling of Ion and Water Transport in the Biological Nanopore ClyA

This study develops a continuum model of the nanopore ClyA to simulate ion and water transport, revealing how ionic strength and voltage affect conductance and electro-osmotic flow.

Aβ(1-42) tetramer and octamer structures reveal edge pores as a mechanism for membrane damage

This paper determines the structures of Aβ(1-42) tetramers and octamers in membrane-mimicking environments and identifies a new mechanism of membrane disruption via hydrophilic edge pores.