Cisplatin toxicity is mediated by direct binding to TLR4 through a mechanism that is distinct from metal allergens
I. K. Domingo, J. Groenendyk, M. Michalak, A. P. Bhavsar
This study shows cisplatin binds directly to TLR4, distinct from nickel, and histidine residues enhance but are not essential for this interaction.
bioRxiv · Jul 6, 2022Pharmacology & Toxicology