Author

A. P. Bhavsar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

C. Delyea· 2 shared I. K. Domingo· 2 shared N. M. Pollock· 2 shared W. T. Allison· 2 shared A. Latif· 1 shared A. M. Rieger· 1 shared A. P. D. Fox· 1 shared B. E. Dubrule· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

C. Delyea

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Adopting orphan receptors: group IX/X transition metals as potential ligands of zebrafish Tlr4 homologs

A. P. D. Fox, T. S. Lee, S. N. Mithaiwala, N. M. Pollock, A. P. Bhavsar, W. T. Allison

The paper shows zebrafish Tlr4 mediates ototoxic responses to transition metals like Ni, Co, and Pt, with knockdown reducing toxicity and human cell line expression showing inflammatory responses.

bioRxiv · Sep 13, 2023 · PreprintZoology

Cisplatin toxicity is mediated by direct binding to TLR4 through a mechanism that is distinct from metal allergens

I. K. Domingo, J. Groenendyk, M. Michalak, A. P. Bhavsar

This study shows cisplatin binds directly to TLR4, distinct from nickel, and histidine residues enhance but are not essential for this interaction.

bioRxiv · Jul 6, 2022Pharmacology & Toxicology

NOD1 is super-activated through spatially-selective ubiquitination by the Salmonella effector SspH2

C. Delyea, S. Y. Luo, B. E. Dubrule, O. Julien, A. P. Bhavsar

This paper identifies SspH2 as an E3 ubiquitin ligase that super-activates NOD1 and NOD2 through spatially-selective ubiquitination, enhancing pro-inflammatory cytokine secretion via the NF-κB pathway.

bioRxiv · Oct 8, 2021 · PreprintMicrobiology

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

G. Babolmorad, A. Latif, N. M. Pollock, I. K. Domingo, C. Delyea, A. M. Rieger, W. T. Allison, A. P. Bhavsar

This paper shows platinum and cisplatin activate TLR4, contributing to ototoxicity, and identifies TLR4 as a target to mitigate cisplatin-induced hearing loss.

The EMBO Reports · Mar 18, 2021Peer-reviewedPharmacology & Toxicology