IL-21 and IFN-α have both opposite and redundant role on human innate precursors and memory B-cell differentiation.
M. Boudigou, M. Michee-Cospolite, P. Hemon, A. Grasseau, C. Le Dantec, E. Porchet, C. Jamin, V. Devauchelle, O. Mignen, D. Cornec, J.-O. Pers, L. Le Pottier, S. Hillion
The paper investigates the roles of IL-21 and IFN-α in B-cell differentiation, identifying a novel NARB+ precursor population with characteristics of marginal zone B cells.
bioRxiv · Mar 31, 2021 · PreprintImmunology