Author

O. Mignen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Grasseau· 1 shared B. Christian· 1 shared B. Domingo· 1 shared C. Bagacean· 1 shared C. Ferec· 1 shared C. Jamin· 1 shared C. Le Dantec· 1 shared C. Le Marechal· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. Grasseau

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Blocking Orai1 constitutive activity inhibits B-cell cancer migration and synergistically acts with drugs to reduce B-CLL cell survival

J. Scaviner, C. Bagacean, B. Christian, Y. Renaudineau, O. Mignen, S. Abdoul-Azize

This study shows that inhibiting Orai1 reduces B-CLL cell survival and migration, and synergizes with existing drugs to enhance therapeutic effects.

bioRxiv · Dec 12, 2023Cancer Biology

IL-21 and IFN-α have both opposite and redundant role on human innate precursors and memory B-cell differentiation.

M. Boudigou, M. Michee-Cospolite, P. Hemon, A. Grasseau, C. Le Dantec, E. Porchet, C. Jamin, V. Devauchelle, O. Mignen, D. Cornec, J.-O. Pers, L. Le Pottier, S. Hillion

The paper investigates the roles of IL-21 and IFN-α in B-cell differentiation, identifying a novel NARB+ precursor population with characteristics of marginal zone B cells.

bioRxiv · Mar 31, 2021 · PreprintImmunology

p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis.

M. Burgos, R. Phillipe, F. Antigny, P. Buscaglia, E. Masson, S. Mukherjee, P. Dubar, C. Le Marechal, F. Campeotto, N. Lebonvallet, M. Frieden, J. Llopis, B. Domingo, P. B. Stathopulos, M. Ikura, , O. Mignen

The paper identifies a p.E152K-STIM1 mutation that disrupts Ca2+ signaling in pancreatic acinar cells, leading to trypsin activation and cell death in pancreatitis patients.

bioRxiv · Jan 22, 2020Cell Biology