Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome
Q. Fei, E. M. Shalosky, R. Barnes, V. C. Shukla, M. N. Ballinger, L. Farkas, R. J. Lee, S. N. Ghadiali, J. A. Englert
This study develops mannosylated lipid nanoparticles to deliver miR-146a to alveolar macrophages, reducing lung inflammation with lower doses in a mouse model of hemorrhagic shock-induced acute respiratory distress syndrome.
bioRxiv · Feb 17, 2023Pharmacology & Toxicology