SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction
M. Narwal, J.-P. Armache, T. Edwards, K. S. Murakami
This study presents cryo-EM structures of SARS-CoV-2 Mpro bound to the nsp7-10 region of pp1a polyprotein, revealing how Mpro interacts with polyproteins and cleaves them sequentially.
bioRxiv · Sep 9, 2022Biophysics