T. Edwards

Influence of solvent, sex, and age on pharmacokinetic and acute behavioral effects of vaporized cannabis extract in mice

This study examines age and sex differences in pharmacokinetics and acute behavioral effects of vaporized cannabis extract in mice using different solvents.

A mycobacterial DNA extraction protocol designed for resource limited settings generates high quality whole genome sequencing

This paper develops a DNA extraction protocol for mycobacteria that produces high-quality sequencing data without requiring cold chain storage or toxic chemicals.

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase producing Enterobacterales

The paper investigates the re-emerging chloramphenicol susceptibility in ESBL-producing Enterobacterales by analyzing genotype-phenotype discordance and molecular mechanisms.

SARS-CoV-2 polyprotein substrate regulates the stepwise Mpro cleavage reaction

This study presents cryo-EM structures of SARS-CoV-2 Mpro bound to the nsp7-10 region of pp1a polyprotein, revealing how Mpro interacts with polyproteins and cleaves them sequentially.

Competent immune responses to SARS-CoV-2 variants in older adults following mRNA vaccination

This study shows older adults have robust cellular immunity and comparable neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination.

GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, but not in Female Mice

Piperacillin/tazobactam resistant, cephalosporin susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types

The paper identifies genetic diversity and resistance mechanisms in E. coli with piperacillin/tazobactam resistance but third-generation cephalosporin susceptibility.

A loss-of-function mutation in IL-17F enhances susceptibility of mice to oropharyngeal candidiasis

This study shows that a loss-of-function mutation in IL-17F increases susceptibility to oropharyngeal candidiasis in mice, but not in heterozygous carriers.

Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B

Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defense

This study shows that ATP released by Candida albicans activates non-peptidergic neurons to enhance anti-Candida immune responses.

A highly multiplexed melt-curve assay for detecting the most prevalent carbapenemase, ESBL and AmpC genes

The paper develops a highly multiplexed HRM assay to detect ESBL, carbapenemase, and AmpC genes in Gram-negative bacteria with high sensitivity and specificity.

Hygienic behaviour selection via freeze-killed honey bee brood not associated with chalkbrood resistance in eastern Australia

This study examines hygienic behaviour in honey bees and finds it is not linked to chalkbrood resistance, despite high baseline hygienic behaviour levels in eastern Australia colonies.