PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
M. O. Ross, Y. Xie, R. C. Owyang, C. Ye, O. N. P. Zbihley, R. Lyu, T. Wu, P. Wang, O. Karginova, O. I. Olopade, M. Zhao, C. He
The paper identifies PTPN2 as a copper sensor that modulates EGFR/CREB signaling and CTR1 transcriptional repression in response to copper level changes.
bioRxiv · Aug 29, 2023 · PreprintBiochemistry