Y. Xie

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Differential Proteomic Analysis of AML Patients at Low and Intermediate Altitudes after Chemotherapy

This study identifies proteomic differences between AML patients at low and intermediate altitudes after chemotherapy, highlighting variations in metabolic and signaling pathways.

Caspase-8-mediated CYLD cleavage boots LPS-induced endotoxic shock.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.

Development and application of GlycanDIA workflow for glycomic analysis

The paper develops GlycanDIA, a DIA-based workflow for glycan identification and quantification, showing improved sensitivity and the ability to detect low-abundant modified glycans.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

Evaluation of the effects of ripening-related genes on fruit metabolites and the associated regulatory mechanisms in tomato

The paper evaluates the effects of ripening-related genes on tomato fruit metabolites and identifies regulatory mechanisms, showing that HY5 mutation increases fructose and glucose levels by modulating SWEET12c expression.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Ultrasound programmable hydrogen-bonded organic frameworks for sono-chemogenetics

This paper introduces ultrasound programmable hydrogen-bonded organic frameworks (HOFs) for targeted drug release and neural circuit modulation in deep brain regions.

High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

This study identifies small molecule inhibitors of Them1, showing they enhance fatty acid oxidation and reduce glucose production in liver cells, suggesting therapeutic potential for NAFLD.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Neural Deterioration and Compensation in Visual Short-term Memory Among Individuals with Amnestic Mild Cognitive Impairment

This study investigates VSTM deficits in aMCI patients, finding reduced accuracy and capacity linked to MTL atrophy and prefrontal compensation.

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

Sustained bacterial (N2O) reduction at acidic pH

The paper identifies a bacterial culture from acidic soil that reduces N2O to N2 at pH 4.5, challenging the assumption that microbial N2O reduction is limited to circumneutral pH.

MolPhase: An Advanced Phase Separation Predictor and an Investigation of Phytobacterial Effector in Plant

MolPhase predicts protein phase separation using physicochemical features and experimental data, showing T3Es undergo homotypic phase separation in vitro and in vivo.

PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

The paper identifies PTPN2 as a copper sensor that modulates EGFR/CREB signaling and CTR1 transcriptional repression in response to copper level changes.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

mRNA condensation fluidizes the cytoplasm

The paper shows that stress-induced mRNA condensation increases mesoscale diffusivity in the cytoplasm, fluidizing it and aiding in the formation of Q-bodies.

Transcriptome mining of RNA viruses (family Totiviridae) in Eimeria necatrix and Eimeria stiedai

The paper identifies and analyzes two new Totiviridae viruses in Eimeria species, revealing phylogenetic insights and suggesting a new genus classification.

The marine natural microbiome mediates physiological outcomes in host nematodes

This study investigates how marine bacteria affect nematode physiology, finding shared and distinct metabolic pathways influencing development and lifespan between L. marina and C. elegans.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Protective effect of plasma neutralization from prior SARS-CoV-2 Omicron infection against BA.5 subvariant symptomatic reinfection

The paper assesses the protective effect of neutralizing antibodies from prior Omicron BA.5 infection against symptomatic reinfection with BA.5, BF.7, CH.1.1, and XBB.1.5 subvariants, finding a strong correlation between antibody titers and reduced reinfection risk.

Microevolution and phylogenomic characterization with perspectives in the 2022-2023 outbreak of child Respiratory Syncytial Virus type A

This study analyzes RSV type A mutations and phylogenetic patterns from global outbreaks to inform epidemiological control and drug development.