AhR-mediated activation of innate lymphocytes restrains tissue-resident memory-like CD8+ T cell responses during contact hypersensitivity
S. Romero-Suarez, M. P. Correia, M. Jeong, V. Ast, M. Platten, V. Sexl, C. Mogler, A. Cerwenka, A. Stojanovic
This study shows that AhR in NKp46+ ILCs limits CHS inflammation by modulating CD8+ TRM cells, with AhR deficiency leading to increased inflammation and TRM-like cells.
bioRxiv · Nov 14, 2022 · PreprintImmunology