V. Sexl

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

This paper creates a mouse model with a STAT5BN642H mutation to study NK-cell leukemia and finds it leads to both indolent and aggressive forms of the disease.

Kinases in motion: impact of protein and small molecule interactions on kinase conformations

This study uses KinCon-reporter technology to analyze conformational changes in disease-associated kinases upon drug, regulatory protein, and pathway activation interactions, revealing insights into therapeutic strategies.

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

AhR-mediated activation of innate lymphocytes restrains tissue-resident memory-like CD8+ T cell responses during contact hypersensitivity

This study shows that AhR in NKp46+ ILCs limits CHS inflammation by modulating CD8+ TRM cells, with AhR deficiency leading to increased inflammation and TRM-like cells.

Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

This paper introduces a method to culture and expand murine alveolar macrophages ex vivo over several months, showing they retain key features and functions.

A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells

This paper introduces a method to generate HPCLSK cells that mimic hematopoietic/leukemic progenitor cells and shows CDK6's role in leukemia formation and homing.