Keap1-resistant ΔN-Nrf2 isoform does not translocate to the nucleus upon electrophilic stress
S. Mikac, A. Dziadosz, M. Padariya, U. Kalathiya, R. Fahraeus, N. Marek-Trzonkowska, E. Chrusciel, Z. Urban-Wojciuk, I. Papak, Łukasz Arcimowicz, T. Marjanski, W. Rzyman, A. Sznarkowska
This paper shows that the ΔN-Nrf2 isoform remains cytoplasmic under electrophilic stress and does not activate transcription, unlike full-length Nrf2.
bioRxiv · Jun 10, 2022 · PreprintCell Biology