A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia
Z. Dong, H. Sepulveda, L. J. A. Vazquez, C. Blouin, J. Fernandez, M. Binder, W.-C. Chou, H.-F. Tien, G. J. Faulkner, S. A. Myers, M. Patnaik, A. Rao
This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.
bioRxiv · Jan 30, 2024 · PreprintCancer Biology