S. A. Myers

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

The paper introduces the BioTAC system to map small molecule interactomes in situ, enabling the identification of both direct and complexed binding proteins with high confidence.

OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis

This study identifies OGT's role in maintaining cell viability by regulating the proteasome/mTOR/mitochondrial axis through amino acid homeostasis and mitochondrial fitness.

Gene flow between two thick-billed grasswren subspecies with low dispersal creates a genomic pattern of isolation-by-distance

This study measures gene flow between two thick-billed grasswren subspecies and finds asymmetric gene flow and isolation-by-distance, with genomic outliers linked to plant community type.

Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides

The paper introduces new anti-O-GlcNAc antibodies for efficient enrichment of native O-GlcNAc modified peptides, identifying over 1,300 unique peptides with reduced sample and time requirements.

Gait variability is affected more by peripheral artery disease than by vascular occlusion

This study compares gait variability in patients with peripheral artery disease (PAD) and healthy controls under rested and reduced blood flow conditions, finding increased variability in PAD and under reduced flow.

CRISPR/Cas9-APEX-mediated proximity labeling enables discovery of proteins associated with a predefined genomic locus in living cells

This paper introduces a method to identify proteins associated with a specific genomic locus in living cells without requiring specific antibodies.