Author

H. Sepulveda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

A. Rao· 2 shared S. A. Myers· 2 shared C. Blouin· 1 shared D. A. Scott· 1 shared G. J. Faulkner· 1 shared H.-F. Tien· 1 shared J. Fernandez· 1 shared L. J. A. Vazquez· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

A. Rao

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia

Z. Dong, H. Sepulveda, L. J. A. Vazquez, C. Blouin, J. Fernandez, M. Binder, W.-C. Chou, H.-F. Tien, G. J. Faulkner, S. A. Myers, M. Patnaik, A. Rao

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.

bioRxiv · Jan 30, 2024 · PreprintCancer Biology

OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis

X. Li, X. Yue, H. Sepulveda, R. A. Burt, D. A. Scott, S. A. Carr, S. A. Myers, A. Rao

This study identifies OGT's role in maintaining cell viability by regulating the proteasome/mTOR/mitochondrial axis through amino acid homeostasis and mitochondrial fitness.

bioRxiv · Sep 19, 2021 · PreprintCell Biology