Constitutive Androstane Receptor contributes towards increased drug clearance in cholestasis
B. Mathur, W. Arif, M. Patton, R. Faiyaz, A. Kalsotra, A. M. Wheatley, S. Anakk
The paper identifies CAR activation as a mechanism for increased drug clearance in cholestasis, showing reduced drug efficacy in cholestatic mice.
bioRxiv · Jan 15, 2019Physiology