Chronic Prestress Regulation of Micro-Heart Muscle Physiology
D. W. Simmons, D. R. Shuftan, J. Guo, K. Oguntuyo, G. Ramahdita, M. K. Munsell, B. Kandalaft, M. Pear, N. Huebsch
This study investigates how tissue geometry affects electrophysiology in engineered heart muscle tissues, revealing a prestress threshold for sodium channel function and the role of PKP2 in electrical remodeling.
bioRxiv · Jul 23, 2022 · PreprintBioengineering