Author

N. Huebsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:electrophysiology· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Tveito· 2 shared B. Charrez· 2 shared B. Siemons· 2 shared G. Ramahdita· 2 shared J. GUO· 2 shared K. E. Healy· 2 shared S. C. Boggess· 2 shared S. Wall· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

A. Tveito

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy

J. GUO, H. Jiang, D. Schuftan, J. D. Moreno, G. Ramahdita, L. Aryan, D. Bhagavan, J. Silva, N. Huebsch

This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.

bioRxiv · Oct 30, 2023 · PreprintBioengineering

Chronic Prestress Regulation of Micro-Heart Muscle Physiology

D. W. Simmons, D. R. Shuftan, J. Guo, K. Oguntuyo, G. Ramahdita, M. K. Munsell, B. Kandalaft, M. Pear, N. Huebsch

This study investigates how tissue geometry affects electrophysiology in engineered heart muscle tissues, revealing a prestress threshold for sodium channel function and the role of PKP2 in electrical remodeling.

bioRxiv · Jul 23, 2022 · PreprintBioengineering

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, G. Neiman, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. Edwards, J. Serrano, M. Snuderl, A. Stahl, , K. E. Healy

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

bioRxiv · Nov 14, 2020Bioengineering

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

F. T. Lee-Montiel, A. Laemmle, L. Dumont, C. S. Lee, N. Huebsch, V. Charwat, H. Okochi, M. J. Hancock, B. Siemons, S. C. Boggess, I. Goswami, E. Miller, H. Willenbring, K. Healy

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

bioRxiv · May 24, 2020 · PreprintBioengineering

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

A. Tveito, K. H. Jaeger, N. Huebsch, B. Charrez, A. G. Edwards, S. Wall, K. E. Healy

This paper develops a computational framework to predict drug effects in mature cardiomyocytes using data from immature human stem cell-derived cardiomyocytes in microphysiological systems.

bioRxiv · Jul 10, 2018Biophysics