Author

M. R. Keddar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-exome sequencing· 2

Frequent Co-Authors

F. D. Ciccarelli· 3 shared A. Acha-Sagredo· 2 shared H. Misetic· 2 shared L. Montorsi· 2 shared M. Bortolomeazzi· 2 shared A. Strange· 1 shared B. Larijani· 1 shared C. Swanton· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

F. D. Ciccarelli

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment

H. Misetic, M. R. Keddar, J.-P. Jeannon, F. D. Ciccarelli

The paper identifies 477 TIME drivers across 32 cancer types, showing their role in cancer evolution and predicting immunotherapy response, with a focus on HNSC.

bioRxiv · Jan 24, 2023 · PreprintCancer Biology

Comparative assessment of genes driving cancer and somatic evolution.

L. Dressler, M. Bortolomeazzi, M. R. Keddar, H. Misetic, G. Sartini, A. Acha-Sagredo, L. Montorsi, N. Wijewardhane, D. Repana, J. Nulsen, J. Goldman, M. Pollit, P. Davis, A. Strange, K. Ambrose, F. D. Ciccarelli

The paper assesses genes driving cancer and somatic evolution, revealing gaps in driver gene compendiums and identifying conserved genes that promote clonal expansion without malignancy.

bioRxiv · Aug 31, 2021 · PreprintCancer Biology

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

M. Bortolomeazzi, M. R. Keddar, L. Montorsi, A. Acha-Sagredo, L. Benedetti, D. Temelkovski, S. Choi, N. Petrov, K. Todd, P. Wai, J. Kohl, T. Denner, E. Nye, R. Goldstone, S. Ward, , F. D. Ciccarelli

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

bioRxiv · Dec 15, 2020 · PreprintCancer Biology