Author

R. Goldstone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

A. de Castro· 2 shared C. Moore· 2 shared E. Mugarza· 2 shared J. Boumelha· 2 shared J. Downward· 2 shared M. Molina-Arcas· 2 shared P. Anastasiou· 2 shared S. de Carne Trecesson· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. de Castro

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

P. Anastasiou, C. Moore, S. Rana, A. de Castro, M. Tomaschko, J. Boumelha, E. Mugarza, C. Blaj, S. de Carne Trecesson, R. Goldstone, J. Smith, E. Quintana, M. Molina-Arcas, J. Downward

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

bioRxiv · Jan 15, 2024Cancer Biology

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

J. Boumelha, A. de Castro, N. Bah, H. Cha, S. de Carne Trecesson, S. Rana, P. Anastasiou, E. Mugarza, C. Moore, R. Goldstone, P. East, K. Litchfield, S.-H. Lee, M. Molina-Arcas, J. Downward

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

bioRxiv · Apr 13, 2023Cancer Biology

SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF

M. Ioannou, D. Hoving, I. V. Aramburu, N. M. De Vasconcelos, M. I. Temkin, Q. Wang, S. Vernardis, V. Demichev, T.-D. Tsourouktsoglou, S. Boeing, R. Goldstone, S. David, K. Klaus Stahl, C. Bode, M. Ralser, V. Papagiannopoulos

This study identifies SIGNR1's role in promoting immune dysfunction during systemic candidiasis by modulating neutrophil lifespan through T cell-derived histones and G-CSF.

bioRxiv · Aug 9, 2021 · PreprintImmunology

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

M. Bortolomeazzi, M. R. Keddar, L. Montorsi, A. Acha-Sagredo, L. Benedetti, D. Temelkovski, S. Choi, N. Petrov, K. Todd, P. Wai, J. Kohl, T. Denner, E. Nye, R. Goldstone, S. Ward, , F. D. Ciccarelli

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.

bioRxiv · Dec 15, 2020 · PreprintCancer Biology