L. Montorsi

Unanticipated interacting features of human gut-associated lymphoid tissues link microbiota, intestinal immunity and autoimmunity

The paper identifies DN2 B cells in human GALT that interact with DC expressing DNASE1L3 and C1Q, linking microbiota, immunity, and autoimmunity.

Disrupted Peyer's patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus

This study examines the impact of COVID-19 on ileal Peyer's patches, finding disrupted microanatomy and germinal centre atrophy independent of local viral load.

Comparative assessment of genes driving cancer and somatic evolution.

The paper assesses genes driving cancer and somatic evolution, revealing gaps in driver gene compendiums and identifying conserved genes that promote clonal expansion without malignancy.

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood

The paper identifies two distinct subsets of human marginal zone B cells through global analysis of lymphoid tissues and blood, revealing differences in their biology and distribution.

Immunogenomic profile of colorectal cancer response to immune checkpoint blockade

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.