Author

M. R. Leung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:microscopy & imaging analysis· 3 Organism:mouse· 3 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1

Frequent Co-Authors

T. Zeev-Ben-Mordehai· 4 shared R. T. Ravi· 3 shared B. Gadella· 2 shared H. Henning· 2 shared M. Zhang· 2 shared P. Maitan· 2 shared A. J. R. Heck· 1 shared B. M. Gadella· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCell Biology

T. Zeev-Ben-Mordehai

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Author profile →

4 papers

Recent·Most cited

Membrane remodeling and matrix dispersal intermediates during mammalian acrosomal exocytosis

M. R. Leung, R. T. Ravi, B. Gadella, T. Zeev-Ben-Mordehai

This study uses cryo-electron tomography to visualize intermediates of acrosomal exocytosis in sperm, revealing structural mechanisms for gradual matrix dispersal and cell integrity maintenance during fertilization.

bioRxiv · Aug 4, 2021Cell Biology

In-cell structures of a conserved supramolecular array at the mitochondria-cytoskeleton interface in mammalian sperm

M. R. Leung, R. Zenezini Chiozzi, M. Roelofs, J. F. Hevler, R. T. Ravi, P. Maitan, H. Henning, M. Zhang, E. Bromfield, S. Howes, B. Gadella, A. J. R. Heck, T. Zeev-Ben-Mordehai

The paper uses cryo-electron tomography to image mitochondria-cytoskeleton interfaces in mammalian sperm, revealing conserved supramolecular arrays composed of glycerol kinase-like proteins.

bioRxiv · Feb 16, 2021 · PreprintCell Biology

The multi-scale architecture of mammalian sperm flagella and implications for ciliary motility

M. R. Leung, M. C. Roelofs, R. T. Ravi, P. Maitan, H. Henning, M. Zhang, E. G. Bromfield, S. C. Howes, B. M. Gadella, H. Gadelha, T. Zeev-Ben-Mordehai

This study uses cryo-electron tomography to image sperm flagella from three mammalian species, revealing structural features that link molecular organization to ciliary motility and evolution.

bioRxiv · Nov 18, 2020Cell Biology

The physiological butyrylcholinesterase tetramer is a dimer of dimers stabilized by a superhelical assembly

M. R. Leung, L. S. Bezouwen, L. M. Schopfer, J. L. Sussman, I. Silman, O. Lockridge, T. Zeev-Ben-Mordehai

This paper determines the cryo-EM structure of human butyrylcholinesterase tetramer, revealing its superhelical assembly mechanism and implications for therapeutic applications.

bioRxiv · Sep 30, 2018Biophysics