Author

J. F. Hevler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. J. R. Heck· 3 shared A. Cabrera-Orefice· 1 shared A. Hutchinson· 1 shared A. J. Heck· 1 shared A. Jankevics· 1 shared A. Lemak· 1 shared A. Potter· 1 shared A. Seitova· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

A. J. R. Heck

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MRPS36 provides a missing link in the eukaryotic 2-oxoglutarate dehydrogenase complex for recruitment of E3 to the E2 core

J. f. Hevler, P. Albanese, A. Cabrera-Orefice, A. Potter, A. Jankevics, J. Misic, R. A. Scheltema, U. Brandt, S. Arnold, A. J. R. Heck

The paper identifies MRPS36 as an essential component of the eukaryotic 2-oxoglutarate dehydrogenase complex, replacing the bacterial PSBD and providing structural insights into its organization.

bioRxiv · Oct 8, 2022 · PreprintBiochemistry

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

E. S. Fischer, C. W. Yu, J. F. Hevler, S. H. McLaughlin, S. L. Maslen, A. J. Heck, S. M. Freund, D. Barford

This study investigates how Mps1 phosphorylation of Mad1 facilitates the assembly of the mitotic checkpoint complex by promoting interactions between Mad1, Cdc20, and Bub1.

bioRxiv · May 16, 2022Biochemistry

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

bioRxiv · Apr 2, 2021Biochemistry

In-cell structures of a conserved supramolecular array at the mitochondria-cytoskeleton interface in mammalian sperm

M. R. Leung, R. Zenezini Chiozzi, M. Roelofs, J. F. Hevler, R. T. Ravi, P. Maitan, H. Henning, M. Zhang, E. Bromfield, S. Howes, B. Gadella, A. J. R. Heck, T. Zeev-Ben-Mordehai

The paper uses cryo-electron tomography to image mitochondria-cytoskeleton interfaces in mammalian sperm, revealing conserved supramolecular arrays composed of glycerol kinase-like proteins.

bioRxiv · Feb 16, 2021 · PreprintCell Biology