Systematic mutational analysis of epitope-grafted ED3's immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant
M. M. Islam, M. Sultana, N. Hasan, M. R. Mahib, M. R. Kulkarni, Y. Kuroda
The paper identifies a chimeric ED3 mutant that generates antisera serospecific to both DENV3 and DENV4, revealing that epitope grafting alone is insufficient for serospecificity transfer.
bioRxiv · Apr 30, 2020Immunology