M. M. Islam

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Alignment Free Phylogeny Construction Using Maximum Likelihood Using k-mer Counts

This paper introduces a model for k-mer frequency change based on a birth-death-migration process to estimate maximum likelihood phylogenies without sequence alignment.

Protein engineering, production, reconstitution in lipid nanoparticles, and initial characterization of the Mycobacterium tuberculosis EfpA drug exporter

The paper describes the engineering, production, and characterization of the Mtb EfpA drug exporter, including its reconstitution in lipid nanoparticles and structural insights.

HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association

The paper shows HIV-1 Vpu forms stable aqueous oligomers via its transmembrane domain self-association, identified through cryoEM, EPR, and size exclusion chromatography.

DNA Repair Function Scores for 2172 Variants in the BRCA1 Amino-Terminus

The paper presents functional scores for 2172 BRCA1 variants using a multiplexed HDR assay, showing 93% sensitivity and 100% specificity in classifying pathogenic and benign variants.

Oligomeric polymorphism of HIV-1 Vpu protein in lipid environment and in solution

This study investigates the oligomeric structures of HIV-1 Vpu protein in solution and lipid environments, revealing novel forms and environmental effects on oligomer stability.

Multiparametric Platform for Profiling Lipid Trafficking in Human Leukocytes: Application for Hypercholesterolemia

The paper develops a high-content imaging platform to quantify lipid trafficking in leukocytes, showing lipid mobilization correlates with LDL uptake and helps distinguish hypercholesterolemia cases.

Better expression profile of CD8 and CD4 gene in uterus of pregnant ewe in comparison to non-pregnant - a novel report

The paper reports higher CD8 and CD4 gene expression in the uterus of pregnant ewes compared to non-pregnant ewes, suggesting their potential as markers for pregnancy detection in sheep.

Honeyweed (Leonurus sibiricus) and Buckwheat (Fagopyrum esculentum) supplemented diet improve growth performance, lipid profile and hematological values of broiler chicks

This study evaluates the effects of honeyweed and buckwheat supplemented diets on broiler chicks, finding that a specific combination improves growth, feed efficiency, and blood lipid profiles.

Systematic mutational analysis of epitope-grafted ED3's immunogenicity reveals a DENV3-DENV4 bi-serospecific ED3 mutant

The paper identifies a chimeric ED3 mutant that generates antisera serospecific to both DENV3 and DENV4, revealing that epitope grafting alone is insufficient for serospecificity transfer.

A systematic mutational analysis identifies a 5-residue proline tag that enhances the in vivo immunogenicity of a non-immunogenic model protein 240 folds

Collagen-based scaffolds with infused anti-VEGF release system as potential cornea substitute for high-risk keratoplasty: An in vitro evaluation

This study develops a collagen-based scaffold with a sustained release of anti-VEGF drug for corneal transplantation and validates its properties in vitro.

Generation of nanometer-size aggregates using Solubility Controlling Peptide tags and their ability to increase a proteins immunogenicity in vivo

This study shows that nanometer-scale protein aggregates can increase immunogenicity in vivo, using BPTI-19A as a model.

Rational nanotoolbox with theranostic potential for medicated pro-regenerative corneal implants

This paper develops a nano toolbox for corneal implants that enables drug release, infection response, regeneration promotion, and in situ monitoring of the corneal environment.