Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of BRCA2 mutated breast cancer
R. K. Hastings, M. R. Openshaw, M. Vazquez, A. B. Moreno, D. Fernandez-Garcia, L. J. Martinson, B. Toghill, K. J. Kulbicki, L. Primrose, D. Guttery, K. Page, C. Richards, A. Thomas, J. Tabernero, R. C. Coombes, , J. A. Shaw
This study uses longitudinal whole-exome sequencing of cell-free DNA to track the evolutionary dynamics of BRCA2-mutated breast cancer over 12 years, identifying key mutations and immune escape mechanisms.
bioRxiv · Jan 10, 2020 · PreprintCancer Biology