Author

J. A. Shaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Richards· 2 shared A. B. Moreno· 1 shared A. K. Zalud· 1 shared A. Thomas· 1 shared B. Toghill· 1 shared D. Fernandez-Garcia· 1 shared D. Guttery· 1 shared D. P. Dulebohn· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

C. Richards

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity

W. K. Boyle, C. Richards, D. P. Dulebohn, A. K. Zalud, J. A. Shaw, S. Lovas, F. C. Gherardini, T. J. Bourret

This study shows DksA regulates RpoS-dependent gene expression in B. burgdorferi, essential for tick transmission and mammalian infectivity, through interactions with RNA polymerase and post-transcriptional control of RpoS.

bioRxiv · Nov 4, 2020Microbiology

Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of BRCA2 mutated breast cancer

R. K. Hastings, M. R. Openshaw, M. Vazquez, A. B. Moreno, D. Fernandez-Garcia, L. J. Martinson, B. Toghill, K. J. Kulbicki, L. Primrose, D. Guttery, K. Page, C. Richards, A. Thomas, J. Tabernero, R. C. Coombes, , J. A. Shaw

This study uses longitudinal whole-exome sequencing of cell-free DNA to track the evolutionary dynamics of BRCA2-mutated breast cancer over 12 years, identifying key mutations and immune escape mechanisms.

bioRxiv · Jan 10, 2020 · PreprintCancer Biology