Author

M. R. Pierce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

S. X. Novak· 2 shared E. R. Cleverdon· 1 shared E. R. Curtis· 1 shared H. Hehnly· 1 shared J. Hougland· 1 shared J. Ji· 1 shared J. L. Hougland· 1 shared L. G. Luyt· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

S. X. Novak

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Author profile →

2 papers

Recent·Most cited

A combined computational-biochemical approach offers an accelerated path to membrane protein solubilization

M. R. Pierce, J. Ji, S. X. Novak, M. A. Sieburg, S. Nangia, J. L. Hougland

This paper combines computational modeling and biochemical screening to identify effective detergents for solubilizing membrane proteins, showing computational predictions better predict solubilization than experimental screening.

bioRxiv · Jun 18, 2023Biochemistry

A remarkably specific ligand reveals ghrelin O-acyltransferase interacts with extracellular peptides and exhibits unexpected cellular localization for a secretory pathway enzyme

M. B. Campana, T. R. Davis, E. R. Cleverdon, M. Bates, N. Krishnan, E. R. Curtis, M. D. Childs, M. R. Pierce, S. X. Novak, Y. Morales-Rodriguez, M. Sieburg, H. Hehnly, L. G. Luyt, J. Hougland

This study identifies a specific ligand that shows GOAT interacts with extracellular ghrelin and facilitates its internalization, revealing new insights into its catalytic mechanism and signaling role.

bioRxiv · Jun 1, 2021 · PreprintBiochemistry